NEW DIMENSIONS OF LEAD NEUROTOXICITY

尽管几十年来的研究和努力，以尽量减少铅 从食物、水、空气和工作场所的接触来看，铅仍然是一种 这个国家和全世界的主要健康问题。 联邦 监管和咨询机构不断降低水平， 根据观察到的不良反应，铅的哪些不良反应值得关注 对人类的影响。 尽管高度精炼的方法已经证明 铅在人群中的不利影响以及铅在环境中的许多影响 细胞和分子水平的记录，相对较少， 已知的关于不利的潜在的关键生物过程 铅对人类和实验动物的影响。 本次会议的第一个目标是提供一个论坛， 从分子水平到临床水平的数据垂直整合。 这一整合将有助于集中目前和未来 在各个层面上进行基于机制的研究， 铅中毒的临床和亚临床表现的神经生物学。 这样，会议将实现其第二个目标，即 识别、阐明和定义新兴和有前途的领域， 基础和应用研究，可能有助于确定 铅神经毒性的机制B基础。 本次会议是第九次在一个成功的国际系列， 会议侧重于神经毒性的选定方面。 四十四 国际公认的权威机构在铅的各个方面 毒性已被邀请参加会议，给论文定义 铅毒性研究现状和未来发展，并提出 出版会议记录的手稿。 迄今为止， 我们接触过的发言者都热情地同意， 参加 这些演讲者是根据他们的专业知识、知识， 对该领域的贡献，以及新的和持续的 有助于了解铅的毒性。 此外，新 调查人员和新出现的调查领域将提供一个 论坛通过国家的最先进的数据演示。 学生奖将是 研究生或住院医生提交的最佳论文， 鼓励和认可学生在这一重要领域的努力。 特别 会议的重点是提供充分的讨论 每届会议结束时的时间，以及 与未来研究方向相关的重要问题。 所收集的 会议的文件将作为特刊出版， 国际期刊《神经毒理学》

Despite the decades of research and efforts to minimize lead exposure from food, water, air, and the workplace, lead continues to be a major health problem in this country and throughout the world. Federal regulatory and advisory agencies have continually lowered the levels at which adverse effects of lead are of concern based on observed adverse effects in humans. Although highly refined approaches have demonstrated adverse effects of lead in human populations and many effects of lead at the cellular and molecular level are documented, relatively little is known regarding the critical biological processes underlying the adverse effects of lead in humans and experimental animals. The first objective of this conference is to provide a forum for vertical integration of data from the molecular to the clinical level. This integration will assist in focusing ongoing and future mechanistic-based research efforts at all levels on the underlying neurobiology of clinical and subclinical manifestations of lead toxicity. In doing so, the conference will achieve its second objective, which is to identify, illuminate, and define the emerging and promising areas of basic and applied research which are likely to contribute to identifying the mechanistic b bases of the neurotoxicity of lead. This conference is the Ninth in a successful series of international conferences focusing on selected aspects of neurotoxicity. Forty-four internationally recognized authorities in various aspects of lead toxicity have been invited to attend the conference, give papers defining the state-of-the-art and future developments in lead toxicity, and submit a manuscript for the publication of the proceedings. To date, 28 of the speakers that we have contacted have all enthusiastically agreed to participate. These speakers were chosen for their expertise, knowledge, contributions to the field, and potential for new and continued contribution to understanding lead toxicity. In addition, new investigators and emerging areas of investigation will be provided a forum via state-of-the-art data presentations. A student award will be given for the best paper presented by a graduate student or resident to encourage and recognize student effort in this important area. Special emphasis at the conference has been devoted to providing ample discussion time at the end of each session, as well as for a panel discussion of important issues related to future research avenues. The collected papers of the conference will be published as a special issue of the international journal, NeuroToxicology.