DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

要求提供赠款以改善净额为24,000人的动物设施 维护AAALAC的平方英尺住房和支持空间 自1977年起获得认证。计划中的改建和设备 购买将允许更换略微充足的高压灭菌器； 将扩大现有的能力，为调查人员提供消毒后的 微隔离笼和用品；并将鼓励增加 微型隔离器在需要严格保护啮齿动物的研究中的使用 来自外来病原体。还建议进行改造，以实现 一个非功能区变成了额外的程序空间，动物收容所， 和实验性手术的目的。其他翻修工程的目的是 专门用于啮齿动物研究的升级空间需要高水平的 与世隔绝。这些计划的实施将有助于确保 住房、畜牧业和动物的使用正在与快速 科学知识和研究技术的变革。 对这些改进的需求源于 授予该机构研究和研究培训的校外奖项 涉及实验动物。校外动物研究的增加 从1985财年的840万美元和91个项目增加到1440万个和107个项目 在1988财年增加了对额外运力的需求 在严格控制的环境中饲养动物，并为其他动物 空间、设备和支持服务。 五年来，资本支出集中在 动物设施涉及380万美元的投资 机构。预期的改进是一个重要的阶段。 设施开发。以满足未来新增教职员工的需求 受聘后，该大学正在建造一座新的医学研究大楼，以 将于1992年投入使用，将提供额外的30-35个动物房间 对于不同的物种。

Grant funds are requested to improve an animal facility of 24,000 net square feet of housing and support space that has maintained AAALAC accreditation since 1977. The planned alterations and equipment purchases would permit replacement of a marginally adequate autoclave; would expand present capacity to provide investigators with sterilized microisolator cages and supplies; and would encourage increased microisolator use in studies that require strict protection of rodents from adventitious pathogens. Also proposed are alterations to transform a non-functional area into added space for procedure, animal holding, and experimental surgery purposes. Other renovations are intended to upgrade space dedicated to rodent research requiring a high level of isolation. Implementation of these plans would help to ensure that housing, husbandry and use of animals are keeping pace with rapid changes in scientific knowledge and research technology. The need for these improvements arises from a substantial growth in extramural awards to this institution for research and research training involving laboratory animals. An increase in extramural animal research from $8.4M and 91 projects in Fiscal Year 1985 to 14.4M and 107 projects in Fiscal Year 1988 has heightened demand for additional capacity to maintain animals in carefully controlled environments and for additional space, equipment, and support services. Over the past five years, capital expenditures for the centralized animal facility have involved a $3.8 million investment by the institution. The contemplated improvements represent an important phase facility development. To meet the needs of additional faculty to be hired, the University is constructing a new medical research building to be occupied in 1992 that will provide an additional 30-35 animal rooms for a variety of species.