Chondroitin sulphate A and the immune system during placental malaria

孕妇及其婴儿容易感染胎盘疟疾。疟疾寄生虫通过与硫酸软骨素A（CSA）结合来感染胎盘。CSA水平在正常妊娠中升高。研究表明，CSA可以抑制免疫细胞功能。本研究将探讨CSA在妊娠期和胎盘型疟疾中的免疫调节功能。CSA可以作为伪装，隐藏疟疾寄生虫从免疫细胞。这可能是一种新的免疫逃避途径。

Pregnant women and their babies are susceptible to placental malaria infection. Malaria parasites infect the placenta by binding to chondroitin sulfate A (CSA). CSA levels increase in normal pregnancy. Studies suggest that CSA can suppress immune cell function. This study will look at the immune modulating function of CSA during pregnancy and placental malaria. CSA may act as camouflage, hiding the malaria parasite from immune cells. This may be a novel immune evasion pathway.