ALLOMETRIC GROWTH IN GIANT TRANSGENIC RODENTS

目的是使用转基因小鼠(MTrGH-Palmiter等人， 1982)作为一个实验模型来研究 GH和IGF-I水平升高对器官和躯体生长的影响。 需要分析的具体问题是，大小和 老年人各器官和肌肉骨骼系统的形态变化 巨型转基因小鼠是一般异速生长效应的结果 (即，它们的相对增长模式的延伸 正常大小的产仔对照)或对 特定的目标器官和区域。假设是 测试的是内部尺寸和比例的所有变化 巨型转基因中的器官和肌肉骨骼系统 老鼠是由一般的大小因素造成的，或者说差异 生长异速生长特征模式的推广 正常大小的对照组。 这一假设将用方法论的方法进行检验。 来自进化形态的研究，通常不是 适用于正常和不正常的生长。这些方法论 与个体发育异速生长(相对生长)有关，异时性 (大小、形状和定时参数的集成)，以及 赖特(1932)大小因素或影响的等级 (一般、小组和特别)。 这项研究与荷尔蒙的控制直接相关 正常和正常个体发育过程中的器官和骨骼比例 异常生长。转基因小鼠提供了一种重要的 长期暴露于空气中的影响研究模型 体内生长激素和IGF-I水平异常高 成长和成年期。这些转基因动物的研究 因此可以提供直接相关的重要信息 对人类发育异常，如巨人症和 肢端肥大症。器官的放射检查或外部检查 骨骼比例是临床上的一个重要步骤。 对这种生长障碍的评估，以及在 生长灵芝疗法的有效性。的研究。 转基因小鼠的比例变化也可能起到一定作用 这两个健康问题。

The objective is to use transgenic mice (MTrGH-Palmiter et al., 1982) as an experimental model for the study of the effects of elevated levels of GH and IGF-I on organ and somatic growth. The specific problem to be analysed is whether the size and shape changes of the organs and musculoskeletal system in the giant transgenic mice results from general allometric effects (i.e. the extension of relative growth patterns of their normal-size littermate controls) or specific effects on particular target organ and regions. The hypothesis to be tested is that all changes in size and proportions of internal organs and the musculoskeletal system in the giant transgenic mice result from general size factors, or the differential extension of patterns of growth allometry characterizing the normal-sized controls. This hypothesis will be tested with methodological approaches drawn from studies of evolutionary morphology and not usually applied to normal and abnormal growth. These methodologies relate to ontogenetic allometry (relative growth), heterochrony (integration of size, shape, and timing parameters), and Wright's (1932) hierarchy of size factors or influences (general, group and special). This research is directly relevant to the hormonal control of organ and skeletal proportions during ontogeny in normal and abnormal growth. The transgenic mice provide an important model for the study of effects of prolonged exposure to abnormally high levels of growth hormone and IGF-I during growth and adulthood. The study of these transgenic animals can therefore provide important information directly relevant to human growth abnormalities such as gigantism and acromegaly. Radiographic or external examination of organ and skeletal proportions is an important step in the clinical evaluation of such growth disorders, as well as in the effectiveness of growth ormone therapies. The study of proportion changes in the transgenic mice may also contribute to both these health issues.