ROLE OF PHYSICAL ACTIVITY IN NIDDM DEVELOPMENT

糖尿病及其相关并发症是主要原因之一。 在美国，死亡和残疾是最重要的。在糖尿病患者中， 非胰岛素依赖型糖尿病(NIDDM)是最常见的类型， 占所有糖尿病病例的90%以上。为了更好地理解 一项在人群中进行了25年的前瞻性研究 在美洲原住民中，皮马印第安人是有记录以来最高的 世界上非胰岛素依赖型糖尿病的发病率。目前这项提议的目的是 调查体力活动作为一种潜在的危险因素的作用 非胰岛素依赖型糖尿病在这一高危人群中的发展。 已经开发了一份活动问卷，用于皮马印第安人 研究收集这一人群中报告的体力活动数据。 利用现有的准确性测试方法，这份问卷被 实践证明，该方法既可行又可靠。出于这个原因，因为 1987年，这份问卷被发放给皮马印第安人 作为研究诊所数据收集计划的一部分的参与者。 这项提议的具体目的是检验这样一种假设，即 皮马印第安人缺乏运动与血糖恶化有关 耐受性，或者作为一个独立的风险因素，或者通过其关联 与肥胖有关。这将通过两种不同的方式进行检查：1)评估 报告的体力活动和 血糖和胰岛素水平与血糖危险因素 以及2)对两国之间关系的前瞻性评估。 体力活动与随后发生血糖的风险 这一人群中的不容忍和肥胖。 这项提案将提供必要的监督和人员 继续收集皮马人口的体力活动数据，以 考虑到体力活动和NIDDM之间的预期关系 接受检查。

Diabetes, with its associated complications, is one of the leading causes of death and disability in the United States. Among those with diabetes, non-insulin-dependent diabetes mellitus (NIDDM) is the most common type, accounting for over 90% of all diabetic cases. To better understand the disease, a prospective study has been underway for 25 years in a population of Native Americans, the Pima Indians, who have the highest documented rates of NIDDM in the world. The purpose of this current proposal is to investigate the role of physical activity as a potential risk factor for the development of NIDDM in this high risk population. An activity questionnaire had been developed for use in the Pima Indian study to collect reported physical activity data in this population. Utilizing available methods of accuracy testing, this questionnaire was demonstrated to be both feasible and reliable. For this reason, since 1987, this questionnaire has been administered to the Pima Indian participants as part of the data collection scheme at the study clinic. The specific aim of this proposal is to test the hypothesis that physical inactivity in the Pima Indians is associated with a worsening of glucose tolerance, either as an independent risk factor, or through its association with obesity. This will be examined in two separate ways: 1) evaluation of the cross-sectional association between reported physical activity and both blood glucose and insulin levels and the risk factors for glucose intolerance; and 2) prospective evaluation of the relationship between physical activity and the subsequent risk of development of glucose intolerance and obesity in this population. This proposal will provide the necessary supervision and personnel for continued collection of physical activity data in the Pima population to allow for the prospective relationship between physical activity and NIDDM to be examined.