GASTROINTESTINAL FUNCTION--SEROTONERGIC CONTROL

胃肠道由自主神经的整合控制。 神经系统、激素、旁分泌和神经内分泌过程。胆量 包含大量的生物活性物质，包装在 分泌颗粒被描述为粘膜的“内分泌-旁分泌”细胞。 在哺乳动物中，大约90%的5-羟色胺含量包含在 胃肠道，主要是在这些分泌颗粒中 “内分泌-旁分泌”细胞。5-羟色胺对 胃肠功能，包括对胃酸分泌的影响， 运动、胃排空和溃疡形成。然而，有一种稀缺的 关于内源性5-羟色胺在 调节肠道功能。 这些研究结合了传统的胃功能方法和 神经解剖学、电生理学和HLPC技术评估 5-羟色胺向胃腔和门脉释放的调控机制 血。5-羟色胺释放对胃功能和胃功能的功能性后遗症 其调节胃排空的作用将被确定。这个 诱导胃5-羟色胺分泌细胞增殖对血管紧张素转换酶活性的影响 胃肠功能将进行评估。这些研究可能会提供 对临床观察到的与以下症状相关的情况的洞察 胃肠道5-羟色胺增生症。这些条件包括 慢性前列腺癌的类癌综合征与内分泌细胞增殖 慢性抗溃疡药物治疗或萎缩性胃酸过缓 胃炎。

The gastrointestinal tract is controlled by the integration of autonomic nervous system, hormonal, paracrine and neuroendocrine processes. The gut contains a large population of biologically active substances packaged in secretory granules in described "endocrine-paracrine" cells of the mucosa. In mammals, approximately 90% of the content of serotonin is contained in the gastrointestinal tract, predominantly in secretory granules of these "endocrine-paracrine" cells. Serotonin produces marked effects on gastrointestinal function, including effects on gastric acid secretion, motility, gastric emptying and ulcer formation. However, there is a paucity of information available regarding the role of endogenous serotonin to mediate gut function. These studies combine conventional gastric functional methodologies with neuroanatomical, electrophysiological and HLPC techniques to assess the control mechanism of serotonin release into the gastric lumen and portal blood. The functional sequelae of serotonin release on gastric function and its role to mediate gastric emptying of the meal will be determined. The effects of induced hyperplasia of gastric serotonin-secreting cells on gastrointestinal function will be assessed. These studies may provide insight to clinically observed conditions with symptomatology related to hyperplasia of gastrointestinal serotonin. Such conditions include carcinoid syndrome and endocrine cell proliferation subsequent to chronic achlorhydria produced by chronic antiulcer drug therapy or atrophic gastritis.