NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION

交感神经系统在精神疾病中起着重要作用。 严重室性心律失常的发生，特别是在 心肌缺血或心肌梗死后。在动物身上 实验性心肌梗死模型的建立 研究将寻求：1)非侵入性地绘制出 心肌交感神经与存活神经的分布 应用放射性核素心肌显像和核素心肌灌注 功能图像；2)将闪烁图像与 交感神经的局部形态由 儿茶酚胺荧光显微镜，并以区域 儿茶酚胺含量、β受体密度和腺苷环化酶 活性，通过生物化学测定；3)确定 交感神经支配对电稳定性的影响 使用程序化刺激技术对心肌进行检测。 这些实验的结果可能会提供重要的新的 缺血性室性心律失常发生机制的研究进展 心脏病，还可以提高对 都有患上这些致命性室性心律失常的风险。

The sympathetic nervous system plays an important role in the genesis of serious ventricular arrhythmias, particularly during myocardial ischemia or after myocardial infarction. In animal models of experimental myocardial infarction, the proposed research will seek: 1) to noninvasively map the distribution of myocardial sympathetic nerves and the distribution of viable perfused myocardium using radionuclide scintigraphy and functional images; 2) to compare the scintigraphic patterns to the regional morphology of sympathetic nerves determined by catecholamine fluorescence microscopy, and to the regional catecholamine content, beta receptor density, and adenylcyclase activity, determined biochemically; 3) to determine the effects of alterations in sympathetic innervation on the electrical stability of the myocardium using programmed stimulation techniques. The results of these experiments may provide important new insights into mechanisms of ventricular arrhythmias in ischemic heart disease, and also may improve identification of patients who are at risk for these lethal ventricular arrhythmias.