DOSIMETRY OF LASER-TISSUE INTERACTIONS

本研究将实验与理论相结合 激光和常规光源的剂量测定说明 在医学上的治疗和诊断应用。 一个目标是 实验技术的发展，以指定组织光学 各种组织类型的特性和测量，以产生库 在紫外-可见-近红外范围内的组织光学特性 江西篇章 第二个目标是计算机模拟辐射输运， 复杂混浊组织。 稳态剂量测定将在 用于可变边界条件的均质和异质组织， 辐射的几何形状。 将研究时变剂量测定法， 热诱导的组织光学性质的变化动态地改变 激光照射期间的剂量测定。 这项研究涉及计算机 模拟、体模组织模型以及体外和体内动物模型 实验 该研究目标将有助于开发治疗 用于剂量测定和诊断的协议和光学设备。 三 临床情况将被认为是重点的一般概念：（1） （2）对色素痣进行筛查， 黑素瘤（3）膀胱和前列腺表面NdYAG照射 通过灌溉降温。 这项工作将在基础研究中进行 医院环境中的实验室，并有动机产生信息 与实际临床应用相关。

The proposed research will integrate experimental and theoretical descriptions of the dosimetry of laser and conventional light sources for therapeutic and diagnostic applications in medicine. One goal is the development of experimental techniques to specify tissue optical properties, and measurement of a variety of tissue types to yield a LIBRARY of tissue optical properties over the ultraviolet-visible-near infrared spectrum. A second goal is COMPUTER SIMULATION OF RADIATIVE TRANSPORT in complex turbid tissues. Steady-state dosimetry will be studied in homogeneous and heterogeneous tissues for variable boundary conditions and geometries of irradiation. Time-variant dosimetry will be studied in which thermally induced changes in tissue optical properties dynamically alter dosimetry during the laser exposure. The research involves computer simulations, phantom tissue models, and in vitro and in vivo animal experiments. The research goals would aid the development of therapeutic protocols and optical devices for dosimetry and diagnostics. Three clinical situations will be considered to focus the general concepts: (1) laser therapy of portwine stain lesions, (2) screening pigmented nevi for melanoma. and (3) NdYAG irradiation of bladder and prostate during surface cooling by irrigation. The work will be conducted in a basic research laboratory within a hospital environment and motivated to yield information pertinent to practical clinical applications.