DOSIMETRY OF LASER-TISSUE INTERACTIONS

拟议的研究将把实验和理论结合起来 激光和常规光源的剂量学描述 治疗和诊断在医学上的应用。其中一个目标是 指定组织光学特性的实验技术的发展 属性，以及各种组织类型的测量以产生文库 组织光学性质的紫外线-可见光-近红外 频谱。第二个目标是计算机模拟辐射输运 复杂的混浊组织。稳态剂量学将在 均质和异质组织的可变边界条件和 辐射的几何形状。将研究时变剂量学，其中 组织光学特性的热诱导变化动态地改变 激光曝光过程中的剂量测定。这项研究涉及计算机 模拟、体模组织模型、体外和活体动物 实验。研究目标将有助于治疗的发展 用于剂量测定和诊断的协议和光学设备。三 临床情况将重点考虑以下几个基本概念：(1) 激光治疗Portwine染色病变，(2)筛查色素痣 黑色素瘤。(3)NdYAG照射膀胱和前列腺表面 通过灌溉来冷却。这项工作将在基础研究中进行 医院环境中的实验室，并有动力提供信息 与实际临床应用相关。

The proposed research will integrate experimental and theoretical descriptions of the dosimetry of laser and conventional light sources for therapeutic and diagnostic applications in medicine. One goal is the development of experimental techniques to specify tissue optical properties, and measurement of a variety of tissue types to yield a LIBRARY of tissue optical properties over the ultraviolet-visible-near infrared spectrum. A second goal is COMPUTER SIMULATION OF RADIATIVE TRANSPORT in complex turbid tissues. Steady-state dosimetry will be studied in homogeneous and heterogeneous tissues for variable boundary conditions and geometries of irradiation. Time-variant dosimetry will be studied in which thermally induced changes in tissue optical properties dynamically alter dosimetry during the laser exposure. The research involves computer simulations, phantom tissue models, and in vitro and in vivo animal experiments. The research goals would aid the development of therapeutic protocols and optical devices for dosimetry and diagnostics. Three clinical situations will be considered to focus the general concepts: (1) laser therapy of portwine stain lesions, (2) screening pigmented nevi for melanoma. and (3) NdYAG irradiation of bladder and prostate during surface cooling by irrigation. The work will be conducted in a basic research laboratory within a hospital environment and motivated to yield information pertinent to practical clinical applications.