MICROWAVE PHASED ARRAY FOR HYPERTHERMIA CANCER THERAPY

本项目的目标是开发一个微波相控阵天线的原型 用于局部肿瘤热疗的施源器。 治疗 电离辐射治疗的有效性可以通过聚焦 对肿瘤进行加热。 利用微波产生 局部热疗已成功地应用于动物和 临床研究。 然而，目前的微波施加器的设计热 只有浅表的肿瘤，必须机械移动才能改变 肿瘤和周围正常组织中的功率分布。 的 拟议的第一阶段研究的具体目标是开发新的 使用微波产生局部肿瘤热疗的技术。 初步研究已导致一种新的设计，微波相控 阵列式热疗器 拟议的第一阶段研究将允许 将现有的设计发展成一个工作的微波原型 热疗施加器系统。 该施用器系统将包括 微波相控阵施加器、微波功率放大器和 分配网络和用于施用器的计算机控制系统。 这种新的微波相控阵施加器系统将有能力 在组织中更有效地聚焦微波能量 可用的临床设备和焦点位置将 电子扫描而不是机械扫描，以产生 均匀的肿瘤温度分布，无过热环境 正常组织 第一阶段研究的结果将为 用于联合放疗和热疗的人体临床试验。

The goal of this project is to develop a prototype microwave phased array applicator for local tumor hyperthermia therapy. The therapeutic effectiveness of ionizing radiation therapy can be improved by the focused application of heat to the tumor. The use of microwaves for the generation of local hyperthermia has been successfully applied in both animal and clinical studies. However, current designs for microwave applicators heat only superficial tumors and must be mechanically moved in order to change the power distribution in the tumor and surrounding normal tissues. The specific aims of the proposed Phase I study are designed to develop new techniques for producing local tumor hyperthermia using microwaves. Preliminary studies have resulted in a new design for a microwave phased array hyperthermia applicator. The proposed Phase I studies will allow development of this existing design into a working prototype microwave hyperthermia applicator system. This applicator system will consist of a microwave phased array applicator, a microwave power amplifier and distribution network, and a computer control system for the applicator. This new microwave phased array applicator system will have the capability of focusing microwave energy more effectively in tissue than presently available clinical devices and the location of the focus will be electronically rather than mechanically scanned in order to produce a uniform tumor temperature distribution without overheating surrounding normal tissues. The results of the Phase I studies will provide a basis for human clinical trials of combined radiation and hyperthermia therapy.