Catalyst Diversity from Chiral Palladacycles

催化方法对提高合成的效率和成本效益具有非常重要的影响，这是开发新药、农用化学品、材料、香料以及进一步的催化剂的关键技术。该计划将为发现基于催化剂形成新方法的用于不对称合成的手性钯催化剂提供平台。这将允许从钯基络合物在一个步骤中产生许多催化剂，其合成已经在理查兹小组中开创。获得多样化的钯催化剂阵列将使选择性的优化和催化剂的数量在许多反应中所需的最小化。此外，新的催化剂生成方案将实现易于固定，通过催化剂的回收和再利用进一步提高化学的可持续性。新平台将应用于新的和不同的手性（即手性）结构的选择性合成，多样性的产生是发现用于药物发现计划的新生物活性化合物过程的核心。

Catalytic methodologies have a very major impact on improving the efficiency and cost effectiveness of synthesis, a key (usually the key) technology for the development of new medicines, agrochemicals, materials, fragrances and, in turn, further catalysts. This programme will generate a platform for the discovery of chiral palladium catalysts for use in asymmetric synthesis based upon a new method of catalyst formation. This will allow numerous catalysts to be generated in just one step from palladium-based complexes, the synthesis of which has been pioneered within the Richards group. Access to a diverse array of palladium catalysts will enable the optimisation of selectivity and the minimisation of the quantity of catalyst required in a host of reactions. In addition, the new catalyst generation protocol will enable facile immobilisation, boosting further the sustainability of the chemistry through catalyst recovery and reuse. The new platform will be applied to the selective synthesis of novel and varied chiral (i.e. handed) structures, diversity generation lying at the heart of the process of discovering new bioactive compounds for application in drug discovery programmes.