TC-99M-LABELED CHEMOTACTIC PEPTIDES FOR ABSCESS IMAGING

甲酰化的趋化肽，具有内源性的Tc-99m结合位点，将 被开发用于定位脓肿、炎症和 感染。这些多肽被设计成具有生物功能 位于分子的一端，而Tc-99m结合部位位于 分子的另一端。在第一阶段，趋化性多肽类似物将 以一步法、直接标记试剂盒配制，并用于动物 对感染和炎症进行定位的研究。初步研究将 包括贴标效率分析和最优贴标定义 ~(99)Tc标记的甲酰肽与淋巴细胞的结合。 在第二阶段，将进行本地化比较研究，使用- ~(111)oxine标记淋巴细胞和~(99m)Tc-人丙种球蛋白参比 材料。

Formylated chemotactic peptides, with endogenous Tc-99m binding sites, will be developed for use in localizing abscesses, inflammations, and infections. The peptides are designed to have the biological function located at one end of the molecule, and the Tc-99m binding site at the other end of the molecule. In Phase I the chemotactic peptide analogs will be formulated in single-step, direct labeling kits, and used in animal studies to localize infections and inflammations. Initial studies will include analysis of labeling efficiency and definition of optimal labeling conditions, and binding of Tc-99m-labeled formyl peptides to lymphocytes. In Phase II, comparative localization studies will be conducted, using In- 111-oxine-labeled lymphocytes and Tc-99m-human gamma globulin as reference materials.