PROGRAM FOR EPITHELIAL CELL PROLIFERATION

建议的努力是为功能开发一个计算机程序， 评估胃肠道中的上皮组织。 的计算机程序 将图像分析与上皮组织动力学和再生相关联将 在现有的LAl便携式计算机内窥镜图像上实现 采集站，在其上可以在真实的时间和真实的 研究人员和临床医生的颜色作为正常G-I的结果 考试 该公司将开发特定的算法， 提供以下定量信息：1）溃疡愈合动力学、面积和 区域属性; 2）傅立叶形状特征，3）颜色和纹理 测量和4）表面深度。 将对结果进行研究 其将表征上皮细胞的动力学和再生速率， 在溃疡愈合过程中测量的组织。 第二阶段将包括外源性因子的影响， 扩大图像采集模式和产品开发范围 一个商业化的低成本的研究和临床使用的包。 第三阶段将包括产品的商业化。 LAl是 目前正在与Fujinon，Inc.在市场营销和分销上 与LAl内窥镜图像和患者数据管理相关的协议 工作站 建议开发的产品可以实现为 独立或作为工作站的附加功能， 将市场。 预计在第二期开发完成后， 努力将存在一个重要的客户安装基础 准备好了更先进的能力，预计将导致拟议的 研究和开发工作。

The proposed effort is for development of a computer program for functional assessment of epithelial tissue in the G-l tract. The computer program relating image analysis to epithelial tissue kinetics and regeneration will be implemented on the existing LAl portable computer endoscopic image acquisition station on which ulcers can be viewed in real time and in true color by researchers and clinicians as a consequence of a normal G-l examination. The company will develop specific algorithms which will provide quantitative information on: 1) ulcer healing kinetics, area and area properties; 2) Fourier shape characteristics, 3) color and texture measurements and 4) surface depth. A study of results will be conducted which will characterize the kinetics and regeneration rates of epithelial tissue as measured in the ulcer healing process. Phase II will include the effects of exogenous agents, accommodation of an expanded range of image acquisition modalities and production development of a commercial low-cost package for both research and clinical use. Phase III will include the commercialization of the product. LAl is currently negotiating with Fujinon, Inc. on a marketing and distribution agreement relative to LAl's endoscopy image and patient data management workstation. The product proposed for development could be implemented as a stand-alone or as an add-on capability to the workstations the Fujinon would market. It is expected that by completion of a Phase II development effort that there will exist a significant installed base of customers ready for the more advanced capabilities expected to result by the proposed research and development effort.