IMMUNOSENSOR FOR DRUG MONITORING

对于滥用药物的有效筛选，简单但毫不含糊 需要可在现场进行的分析方法。这 该项目旨在开发一种用于检测药物的免疫传感器 滥用职权。虽然我们的项目专注于苯甲酰ecGonine的检测， 可卡因的主要尿代谢物，免疫传感器技术可以 很容易适应抗体可用的其他物质， 包括治疗药物和其他生理活性化合物。 免疫传感器的操作是一步法，它不 需要与免疫分析相关的通常步骤，例如移液， 加入试剂，人工分离和混合；一次性传感器 只需浸入生物介质(尿液、血液、唾液)。这个 产生的信号将用现有的技术进行监控， 为测量血糖而开发的。一旦传感器被浸泡 在生物介质中，化验将在至少3到10分钟内完成 10分钟，完成后无需停止反应。

For the efficient screening of drugs of abuse, simple but unambiguous analytical methods are required which can be performed on-site. This project is designed to develop an immunosensor for the detection of drugs of abuse. While our project is focused on the detection of benzoylecgonine, the major urinary metabolite of cocaine, immomunosensor technology can be readily adapted to other substances for which antibodies are available, including therapeutic drugs and other physiologically active compounds. Operation of the immunosensor is a single-step procedure which does not require the usual steps associated with immonoassays such as pipetting, adding of reagents, manual separation and mixing; the disposable sensor need only be dipped into the biological medium (urine, blood, saliva). The signal generated will be monitored with existing technology that has been developed for the measurement of blood glucose. Once the sensor is dipped in the biological medium, the assay will be complete in a minimum of 3 to 10 minutes, without the need to stop the reaction when it is complete.