150 NSEC ENCODING SR PROTEIN CRYSTALLOGRAPHY DETECTORS

描述(改编自研究人员摘要)：X射线结晶学 是研究生物体结构的主要技术 蛋白质。详细了解它们在过程中的构象变化 一系列的生化反应，如酶的活性，对精确的 对化学结构、物理结构之间关系的理解 拓扑结构和生化活性。这些中间体是暂时的 必须用时间分辨结晶学来研究状态。即将到来 储存环将提供足够的x射线通量来研究 毫秒和纳秒之间的时间制度，如果集成2-D探测器可以 设计成可以在150毫微秒的间隔内读出 由这些存储环发出的PSEC x射线爆发。高质量集成 存在检测器(例如，ccd)，但它们受其顺序的限制 读出方案。这项工作解决了读出问题，通过开发一个 并行处理2-D检测器(1帧)的所有像素的方法， 将这些值数字化并存储在本地内存中，直到 实验，大约1000帧，当所有数据都转储为永久数据时 以正常数据总线速率存储。在此第二阶段工作中，这些概念 将在一维探测器中实现，该探测器具有可堆叠的几何结构， 将在第三阶段建立一种2-D探测器组装的方法。

DESCRIPTION (Adapted from investigator's abstract): X-ray crystallography is the principal technique for studying the structure of biological proteins. Detailed knowledge of their conformational changes in the course of biochemical reactions such as enzyme activity are critical to a precise understanding of the relationships between chemical structure, physical topology and biochemical activity. Being transient, these intermediate states must be studied with time resolved crystallography. Upcoming storage rings will provide sufficient x-ray flux to study reactions in the time regime between msec and nsec, if integrating 2-D detectors can be devised which can be read out in the 150 nsec intervals between the 100 psec x-ray bursts emitted by these storage rings. High quality integrating detectors exist, (e.g. CCDs) but they are limited by their sequential readout schemes. This work addresses the readout problem by developing a method to process all the pixels of a 2-D detector (1 frame) in parallel, digitizing and storing the values in local memory until the end of an experiment, about 1000 frames, when all the data are dumped to permanent storage at normal data bus rates. In this Phase II effort these concepts will be implemented in a 1-D detector having a "stackable" geometry which will establish an approach to 2-D detector assembly in Phase III.