METALLO-SULFUR COMPLEXES AS MODELS FOR ELECTRON TRANSFER PROTEINS

金属-二硫酸盐络合物和金属二硫化物的化学 络合物将作为金属硫酸盐的模型体系进行研究 电子传递蛋白，如无处不在的铁-硫 蛋白质。推测这些金属蛋白可以获得 部分S-S键形成的额外还原能力 通过两个相邻的金属结合硫代化合物的相互作用。 这一假设的证据来自于一些例子 金属硫酸盐络合物，其中硫的分离是相当大的 小于预测的非粘合最近邻接触 硫原子。金属硫络合物将在哪里合成 二硫酸盐/二硫化物对是可逆的。二硫代硫酸盐 将用高价金属离子制备络合物，而 二硫化物与低价金属离子形成络合物。 硫酸盐络合物的氧化和还原 将对二硫化物络合物进行研究，以提供进一步的 二硫酸盐/二硫化物对作为来源的证据 增加了电子转移蛋白的还原能力。

The chemistry of metal-dithiolate complexes and metal disulfide complexes will be studied as model systems for metallo-thiolate electron transport proteins such as the ubiquitous iron-sulfur proteins. It is proposed that these metalloproteins can obtain additional reducing power by the formation partial S.S bonds through interaction of two adjacent metal-bound thiolates. Evidence for this hypothesis comes from a number of examples of metal-thiolate complexes where the S.S separations are considerably smaller than the predicted nearest neighbor contact of non-bonded sulfur atoms. Metallosulfur complexes will be synthesized where the dithiolate/disulfide couple is reversible. Dithiolate complexes will be prepared with high-valent metal ions while disulfide complexes will be prepared with low-valent metal ions. The oxidation of the thiolate complexes and the reduction of the disulfide complexes will be studied in order to provide further evidence for the dithiolate/disulfide couple serving as a source of increased reducing power in electron transfer proteins.