SHARED INSTRUMENT GRANT

这些工具将支持由美国国立卫生研究院资助的大量不同的研究。 激素(松弛素)、铁蛋白、T细胞抗原和 受体、肿瘤抗原、细胞内蛋白酶活性部位、 鱼类免疫球蛋白M的结构及其大分子组分的结构变化 结缔组织。在每一种情况下，研究都受到数量的限制 可供选择的样品。增加了一个气相定序器，高 灵敏的氨基酸分析仪和多肽合成器将允许 在这些研究领域中的任何一个领域都取得了重大进展。除了……之外 灵敏度更高这些仪器比老式仪器更快 因此将使我们能够适应8-10的实验需求 蛋白质化学设施的偶尔使用者。

The instruments will support a large number of diverse NIH-funded studies. Structural studies of hormones (relaxin), ferritin, T-cell antigens and receptors, tumor antigens, active sites of intracellular proteases, the structure of fish IgM, and structural changes in macromolecular components of connective tissues. In every case the studies are limited by the amount of sample available. The addition of a gas phase sequencer, high sensitivity amino acid analyzer, and peptide synthesizer will allow significant advances in any of these areas of research. In addition to greater sensitivity these instruments are faster than the older instruments and will therefore allow us to accommodate the experimental needs of 8-10 occasional users of the protein chemistry facility.