SINGLE CRYSTAL X-RAY DIFFRACTION FACILITY

此建议是为购买一个完整的单晶X射线 用于数据收集、求解和细化的衍射仪系统 分子结构 该系统由衍射仪组成 配备低温设备和专用计算机系统 所有的晶体学计算。 该仪器将由 X射线晶体学实验室，为 广泛的与健康有关的研究项目，包括： 不饱和聚烯烃和烃之间的可能关系 致癌作用;合成的辅致癌物和二萜具有强大的 细胞毒性特性;评价可能的抗病毒作用 高对称性缩聚脂环分子的合成 生物活性生物碱和氨基酸衍生的天然产物; 过渡金属大环化合物作用模式的构建与分析 仿生化学中的络合物;螯合双氧载体的发展 用于便利运输;海洋天然产物的生物合成 和活性微生物代谢物;前手性反应的立体化学 和前前手性中心;核黄素和相关化合物的生物合成; 与核酸碱基的多重氢键;以及更多。

This proposal is for the purchase of a complete single crystal X-ray diffractometer system for data collection and solution and refinement of molecular structures. The system is to consist of a diffractometer equipped with a low-temperature apparatus and a dedicated computer system for all crystallographic calculations. The instrument will be used by the X-Ray Crystallographic Laboratory to provide structure determinations for a wide range of health-related research projects that include: analysis of possible relationships between unsaturated polyolefins and hydrocarbon carcinogenesis; synthesis of cocarcinogens and diterpenes having powerful cytotoxic properties; evaluation of the possible antiviral role of polycondensed alicyclic molecules of high symmetry; synthesis of biologically active alkaloids and amino acid derived natural products; construction and analysis of mode of action of macrocyclic transition metal complexes in biomimetic chemistry; development of chelate dioxygen carriers for use in facilitated transport; biosynthesis of marine natural products and active microbial metabolites; stereochemistry of reactions at prochiral and proprochiral centers; biosynthesis of riboflavin and related compounds; multiple hydrogen bonding to nucleic acid bases; and much more.