cell-cell adhesive force in vascular development

该项目旨在利用突破性的新方法来可视化血管发育中的细胞-细胞粘附力。血管系统的发育是脊椎动物胚胎发育最早的事件之一。长期以来，人们已经确定新血管形成的一个主要因素是物理力，这可以通过组织形态发生过程中的血流或细胞-细胞相互作用产生。该项目计划利用斑马鱼的实时成像和新一代生物传感器来更深入地了解力是如何控制血管形成的。

This project aims to utilize groundbreaking new approaches to visualize cell-cell adhesive forces in vascular development. Vascular system development is one of the earliest events in the vertebrate embryo. It has long been established that one major contributor to the formation of new vessels is physical force, which can be generated through blood flow or cell-cell interactions during tissue morphogenesis. The project plan utilizes live imaging in zebrafish and a new generation of biosensors to gain a vastly deeper understanding of how force controls vessel formation.