Combining human genetics with single-cell genomics to unravel the differentiation dynamics of human induced pluripotent stem cells

我们现在有能力将成年人的成熟细胞重新编程为多能干细胞，从而提高了使用患者自身细胞治疗目前无法治愈的疾病的可能性。我的项目将提供一个更好的理解人与人之间的遗传变异在细胞分化过程中个体细胞之间基因表达和调控的变异性中所起的作用。我还将开发统计和软件工具来进行这些分析。

We now have the ability to reprogram mature cells from an adult human into pluripotent stem cells, raising the possibility of using a patient’s own cells for treating currently incurable diseases. My project will provide a better understanding of the role genetic variation between people plays in the variability of the expression and regulation of genes between individual cells during the cell differentiation process. I will also develop statistical and software tools to conduct these analyses.