Communication between calcium ion channels in skeletal muscle excitation-contraction coupling

衰老、受伤、药物或基因缺陷会导致肌肉无力、妨碍运动、影响生活方式，并导致健康状况不佳和骨质疏松症。为了移动信号从我们的大脑传递到肌肉，其中一个钙离子通道检测到信号并告诉另一个钙离子通道打开并释放钙离子开始收缩。该项目将为开发药物铺平道路，通过记录这些通道之间相互作用的部位来帮助治疗肌肉疾病。

Ageing, injury, drugs or genetic defects cause muscle weakness, prevent exercise, compromise life style and contribute to poor health and osteoporosis. In order to move signals travel from our brain to muscles, where one calcium ion channel detects the signal and tells a second calcium channel to open and release calcium ions to initiate contraction. The project will pave the way for developing drugs to help with muscle disorders by trageting the site of interaction between the channels.