A PHASE III TRIAL OF A LOW FAT DIET IN STAGE II BREAST C

乳腺癌仍然是美国妇女癌症死亡的主要原因。 虽然发病率和死亡率有所改善， II期乳腺癌患者的辅助化疗， 这个群体是重要的。 该项目旨在进一步影响这一点 通过使用另一种治疗方式，营养 干预 膳食脂肪对乳腺癌发病率的影响 流行病学数据支持癌症。 是否增加了 膳食脂肪摄入量也影响复发尚未调查。 但是，超重和肥胖的妇女有更大和更早的复发 乳腺癌的发病率高于正常体重的患者。 本研究调查了营养咨询对获得一个 低膳食脂肪摄入量（20%的热量）对II期复发率的影响 接受辅助化疗的乳腺癌患者。 患者将 在住院前用营养史和日记进行评估 心理治疗 受试者将被随机分配至对照组或 治疗组。 营养治疗将包括两个人 以及使用特定技术鼓励遵守的小组会议 限制脂肪摄入量 将对患者进行脂肪评估 治疗期间每月一次，治疗后每三个月一次 化疗已经完成。 对照组患者将在同一时间接受评价。 的间隔 随访将持续5年或直至复发。

Breast cancer remains the primary cause of cancer death in American women. Although some improvement in morbidity and mortality has resulted from adjuvant chemotherapy in Stage II breast cancer patients, the death rate in this group is significant. This project seeks to impact further on this subset of patients by utilizing another treatment modality, nutritional intervention. The influence of dietary fat on the incidence of breast cancer has been supported by epidemiological data. Whether an increase in dietary fat intake also influences recurrence has not been investigated. However, overweight and obese women have a greater and earlier recurrence rate of breast cancer than patients of normal weight. This study investigates the influence of nutritional counseling to attain a low dietary fat intake (20% of calories) on the recurrence rate of Stage II breast cancer patients receiving adjuvant chemotherapy. Patients will be evaluated with nutritional histories and diaries prior to the institution of therapy. Accessioned patients will be randomized to control or treatment groups. Nutritional treatment will consist of both individual and group sessions which use specific techniques to encourage compliance with the restricted fat intake. Patients will be evaluated regarding fat intake monthly during the treatment period and every three months after chemotherapy is completed. Control patients will be evaluated at the same intervals. Follow-up will continue for five years or until recurrence.