A PHASE III TRIAL OF A LOW FAT DIET IN STAGE II BREAST C

乳腺癌仍然是美国女性癌症死亡的主要原因。 尽管发病率和死亡率有所改善的原因是 二期乳腺癌患者辅助化疗的死亡率 这一群体意义重大。该项目旨在进一步影响这一点 通过利用另一种治疗方式--营养 干预。膳食脂肪对乳房发病率的影响 癌症得到了流行病学数据的支持。是否会增加 饮食中的脂肪摄入也会影响复发，目前还没有进行研究。 然而，超重和肥胖的女性有更大和更早的复发 乳腺癌的发病率高于正常体重的患者。 这项研究调查了营养咨询对达到 饮食低脂肪摄入(卡路里的20%)对II期复发率的影响 接受辅助化疗的乳腺癌患者。病人将会是 在入院前根据营养史和日记进行评估 接受治疗的机会。入选的患者将随机分为对照组或 治疗组。营养治疗将包括两个人 以及使用特定技术鼓励合规的小组会议 脂肪摄入量受到限制。将对患者进行关于肥胖的评估 治疗期间每月及治疗后每三个月摄取一次 化疗结束了。对照患者将在同一时间接受评估 间隔时间。随访将持续五年或直至复发。

Breast cancer remains the primary cause of cancer death in American women. Although some improvement in morbidity and mortality has resulted from adjuvant chemotherapy in Stage II breast cancer patients, the death rate in this group is significant. This project seeks to impact further on this subset of patients by utilizing another treatment modality, nutritional intervention. The influence of dietary fat on the incidence of breast cancer has been supported by epidemiological data. Whether an increase in dietary fat intake also influences recurrence has not been investigated. However, overweight and obese women have a greater and earlier recurrence rate of breast cancer than patients of normal weight. This study investigates the influence of nutritional counseling to attain a low dietary fat intake (20% of calories) on the recurrence rate of Stage II breast cancer patients receiving adjuvant chemotherapy. Patients will be evaluated with nutritional histories and diaries prior to the institution of therapy. Accessioned patients will be randomized to control or treatment groups. Nutritional treatment will consist of both individual and group sessions which use specific techniques to encourage compliance with the restricted fat intake. Patients will be evaluated regarding fat intake monthly during the treatment period and every three months after chemotherapy is completed. Control patients will be evaluated at the same intervals. Follow-up will continue for five years or until recurrence.