NUTRITION COORDINATING CENTER

本提案的总体目标是设计一个高质量的 营养协调中心（NCC）将为 MDRD研究并支持该研究的主要目的，以测试 假设营养变量，特别是膳食蛋白质 和磷，并与慢性肾脏病的进展有关 疾病 为了实现这一目标，NCC将努力 与MDRD临床中心合作，数据 协调中心、其他中央单位和 国家糖尿病、消化和肾脏疾病研究所 以及卫生保健融资管理局。 的 拟议的NCC的主要职责是：1）设计 营养评估、干预和随访方案。 2)设计和/或选择和完善措施， 估计个体参与者的依从性以及 随机研究组。 3)开发适当的材料 用于评估、干预、跟进、合规性监测， 培训、认证和干预评估。 4)设计与 对临床中心人员进行适当的培训 参与营养评估程序， 干预和后续活动。 5)分析饮食数据， 设计分析，为临床中心提供最大反馈 在随机分组中的依从性模式。 6)协助 制定监测营养适足性的程序。

The overall objective of this proposal is to design a high quality Nutrition Coordinating Center (NCC) which would serve the MDRD Study and support the major aim of that study to test hypothesis that nutritional variables, specifically dietary protein and phosphorus, and related to the progression of chronic renal disease. In order to fulfill this objective the NCC will work collaboratively with the MDRD clinical centers, the Data Coordinating Center, other central units, and the staffs of the National Institute of Diabetes and Digestive and Kidney Diseases as well as the Health Care Financing Administration. The primary responsibilities of the proposed NCC will be: 1) Design the protocol for nutrition assessment, intervention, and follow-up. 2) Design and/or selection and refinement of measures for estimating compliance in individual participants as well as the randomized study groups. 3) Develop the appropriate materials for assessment, intervention, follow-up, compliance monitoring, training, certification, and intervention evaluation. 4) Design and implement appropriate training for clinical center personnel involved with nutrition assessment procedures, and nutrition intervention and follow-up activities. 5) Analyze dietary data and design analyses to provide maximum feedback to clinical centers on compliance patterns within randomized groups. 6) Assist in the development of procedures for monitoring nutritional adequacy.