CRYO-ROP PARTICIPATING CENTER

这是一份申请书，申请成为 冷冻疗法治疗早产儿视网膜病变的研究 CYRO-ROP研究 主要包括两个研究部分：（1）临床试验， 冷冻治疗在致盲中的安全性和有效性 重度、高危、ROP;（2）自然史研究（雅阁 与ROP的国际分类）的早产儿视网膜病变 极低出生体重婴儿（小于1，250克）。 在这份提案中，我们记录了我们眼科医生团队的能力， 和产科医生登记，每年132名极低出生体重婴儿 在自然史研究中存活了至少28天的人。 我们 预计这些婴儿中有8到10人也会患上视网膜病， 早产严重到足以成为合格的登记， 临床试验，另外三到五名患者将被转诊 参加我们的研究

This is an application to become one of the cooperating study centers in the Cryotherapy for Retinopathy of Prematurity Study. The CYRO-ROP Study consists of essentially two research components: (1) A clinical trial of the safety and efficacy of cryotherapy in reducing blindness in eyes with severe, high, risk, ROP; and (2) a study of the natural history (in accord with the international classification of ROP) of retinopathy of prematurity in very low birth weight infants (less than 1,250 grams). In this proposal, we document the ability of our group of ophthalmologists and neonatologists to enroll, each year 132 very low birth weight infants who have survived at least 28 days in the natural history study. We anticipate that eight to ten of these infants will also develop retinopathy of prematurity severe enough to become eligible for enrollment to the clinical trial, and an additional three to five patients will be referred to our study for enrollment to that trial.