ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

虽然酒精明显会导致心理过程的改变 也许是因为这些影响是如此之大， 如此普遍以至于很难描述。 的 全球业绩衡量标准通常用于记录 影响，虽然清楚地表明他们的存在，往往提供 关于具体作用部位或作用机制的信息很少。 本研究旨在分析酒精的单独影响 对周围神经，感觉，认知和运动系统， 事件相关脑电位 这些潜力是 在性能提供的广泛背景下进行研究， 心理生理学、神经心理学、神经放射学和 神经精神病学数据。 酒精的影响在三类中进行了研究， 受试者：1）急性给药的影响进行了检查， 正常志愿者的剂量-反应关系， 影响的时间过程以及与血液酒精的关系 水平; 2）研究脑电活动，结合 神经心理学数据，在社会饮酒者中，试图分析 适度饮酒的影响; 3） 戒酒者，包括酗酒相关者 精神损害，研究缺陷的特征， 检查短期和长期的恢复效果，如果有的话， 禁欲，并检查各种治疗的疗效 战略布局

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these effects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects, while demonstrating clearly their presence, often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive and motor systems using event related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: 1) The effects of acute administration are examined in normal volunteers with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; 2) Brain electrical activity is studied, in conjunction with neuropsychological data, in social drinkers in an attempt to assay the effects of moderate levels of alcohol consumption; 3) Abstaining alcoholics including those with alcoholism-related mental impairment, are studied to characterize the deficits, to examine the short- and long-term recovery effects, if any, during abstinence, and to examine the efficacy of various treatment strategies.