BARBADOS EYE STUDY READING CENTER

开角型青光眼是黑人视力受损的主要原因 人口。临床经验表明有一种异常高的 西德克萨斯州巴巴多斯的青光眼风险，那里的大多数公民都是非洲人 下降。这种疾病是导致失明的主要原因，表现为 早期并伴有严重的视力丧失。一项流行病学研究是 提出的主要目标是：a)衡量 青光眼及其相关损害，b)评估其风险 因素，以及c)获取数据以制定预防措施 或控制视力丧失。这项拟议的研究将是第一次 覆盖整个国家的全面青光眼研究。因为 这种疾病是黑人人口中的一个主要问题，其目标是 这项拟议的研究具有广泛的公共卫生意义。 这项研究的次要目标是衡量流行率和 评估老年性白内障、黄斑的危险因素 变性和糖尿病视网膜病变。基于人口的 关于这些疾病的流行病学数据有限或根本不存在 对于黑人人口；拟议的研究将提供这样的 以有限的额外成本提供信息。 上述目标将通过随机抽取以下样本来实现 4 000名40-84岁的人在卫生部综合诊所就诊。 参与者可以测量眼压， 视野、视力、屈光度、身高、体重和血液 压力，眼底照片和医学采访， 家族史等危险因素史。验血将会是 对病例和非病例样本进行了分析。 BES的眼底照片阅读中心将评估 研究中所有参与者的眼底照片。光学的 将评估视盘是否有青光眼改变。糖尿病和 与年龄相关的黄斑变化也将被记录下来。 眼底照片将提供眼底的评估 所有参与者的病理学。最终的诊断将是 由协调中心根据积极的调查结果确定 临床检查和眼底照片。

Open angle glaucoma is a major cause of visual impairment in Black populations. Clinical experience suggests an unusually high glaucoma risk in Barbados, W.I., where most citizens are of African descent. The disease is the major cause of blindness, presenting early and with advanced visual loss. An epidemiologic study is proposed with the major goals of a) measuring the prevalence of glaucoma and its associated impairment, b) evaluating its risk factors, and c) obtaining data to develop interventions to prevent or control visual loss. The proposed research would be the first comprehensive glaucoma study to cover an entire country. Because the disease is a major problem in Black populations, the aims of the proposed study are of widespread public health significance. The secondary goals of the study are to measure prevalence and evaluate risk factors for age-related cataract, macular degeneration, and diabetic retinopathy. Population based epidemiologic data on these diseases are limited or non-existent for Black populations; the proposed study would provide such information at limited additional cost. The above goals would be attained by examining a random sample of 4000 persons 40-84 years in a Ministry of Health polyclinic. Participants could have measurements of intraocular pressure, visual fields, visual acuity, refraction, height, weight, and blood pressure, as fundus photographs and an interview on medical, family, and other risk factor history. Blood testing would be performed on cases and a sample of non-cases. The Fundus Photograph Reading Center of the BES will evaluate the fundus photographs of all participants in the study. The optic discs will be evaluated for glaucomatous changes. Diabetic and age-related changes of the macula will also, be recorded. The fundus photographs will provide an evaluation of fundus pathology on all participants. The final diagnosis will be determined by the Coordinating Center based on positive findings of the clinical examination and the fundus photographs.