BEHAVIOR FACTORS IN BLOOD PRESSURE REGULATION

饮食和行为因素已经被牵连在发展中， 原发性高血压通过流行病学研究，但 病理生理机制，这些因素，或独立 或协同作用，影响长期血压调节仍然是 明确了 动物研究表明，高钠摄入会导致 当且仅当受试者同时暴露于 反复出现的行为压力 本项目涉及神经内分泌因素， 改变钠调节的神经元在行为性的条件下被激活， 压力，当与高钠摄入量相结合时，会导致 血压. 在第一项研究中，医学院的学生 氯化钠或安慰剂片剂，每日一次，持续两周 考试前和夏季两周。 高 考试准备期间的钠摄入与 收缩压和平均血压的增加大于高钠 夏季摄入量和准备期间通常的钠摄入量 期 状态焦虑与血象变化显著相关 在高钠组中观察到压力。 第二项研究是 旨在复制高血压的收缩压和平均压效应， 考试准备条件下的钠摄入量。 尿排泄数据 并表明符合钠操作。 血清中循环钠泵抑制物的分析 考试准备期间正在进行中。 结果 这与行为压力和钠摄入量 对长期血压调节有协同作用。

Dietary and behavioral factors have been implicated in the development of primary hypertension through epidemiological studies, but the pathophysiological mechanisms by which these factors, either independently or synergistically, affect long-term blood pressure regulation remain to be clarified. Animal studies have shown that high sodium intake engenders sustained hypertension if, and only if, the subject is concurrently exposed to recurrent behavioral stress. The present project addresses the hypothesis that neuroendocrine factors, which alter sodium regulation are activated under conditions of behavioral stress and, when combined with a high sodium intake, result in elevated blood pressure. In the first study, medical students consumed either sodium chloride or placebo tablets daily for two weeks immediately preceding examinations and for two weeks during the summer. The high sodium intake during the exam preparation period was associated with greater increases in systolic and mean blood pressure than the high sodium intake during the summer and the usual sodium intake during the preparation period. State anxiety was significantly related to the changes in blood pressure observed in the high sodium group. A second study has been designed to replicate the systolic and mean pressure effects of the high sodium intake under conditions of exam preparation. Urinary excretion data were obtained and indicate compliance with the sodium manipulation. Analysis for circulating inhibitors of the sodium pump in serum collected during the exam preparation period is in progress. The results are consistent with the hypothesis that behavioral stress and sodium intake have synergistic effects on long-term blood pressure regulation.