STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的重点是涉及约束的机制， 氧气转化为血红蛋白以及氧气向组织的运输。 重点放在这些功能受损的方式上， 随着年龄的变化而变化。 这些研究集中在氧化的 血红蛋白，产生非功能性血红蛋白，同时 释放氧自由基。 这些氧化过程的增强 在低氧条件下，正在探索作为组织来源的可能性。 和器官损伤，这将在衰老过程中加剧。 研究是 还包括针对整个系统的稳定性的 红细胞和红细胞膜。

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.