AGE EFFECTS ON BLOOD PRESSURE AND CIRCULATING SODIUM-PUMP INHIBITORS

流行病学研究表明，平均血压和 高血压患病率均随年龄增长而增加。 可能发挥的作用 膳食钠摄入量在血压增龄中的作用 个人已经被记录在案，但几乎没有信息可用 关于可能与年龄相关的循环激素变化， 影响钠通过血管平滑肌的转运。 本 研究评估了两种循环水平的个体差异 钠泵抑制激素作为年龄相关变化的预测因子 在静息血压中。 晨起仰卧位血压和 在巴尔的摩测量内源性哇巴因和洋地黄样因子 符合纳入标准的老年人纵向研究 的搜索. 该研究还调查了可能的差异， 循环钠泵抑制剂作为种族和性别的函数。 支持以下假设的数据： 静息血压和循环钠泵抑制剂可能 导致药物和非药物干预， 高血压，关注钠泵抑制剂及其决定因素。

Epidemiological studies have shown that mean blood pressure and the prevalence of hypertension both increase with age. A possible role for dietary sodium intake in the blood pressure increase in aging individuals has been documented, but little information is available concerning possible age-associated changes in circulating hormones that affect sodium transport across vascular smooth muscle. The present study assesses individual differences in levels of two circulating sodium-pump inhibiting hormones as predictors of age-associated changes in resting blood pressure. Morning supine blood pressure and endogenous ouabain and digitalis-like factor are measured in Baltimore Longitudinal Study on Aging participants who meet the inclusion criteria. The study also investigates possible differences in circulating sodium-pump inhibitors as a function of race and gender. Data supporting the hypothesis of a positive correlation between resting blood pressure and circulating sodium-pump inhibitors could lead to pharmacological and nonpharmacological intervention in hypertension focusing on sodium-pump inhibitors and their determinants.