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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES

IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
裂殖子侵入红细胞受体的鉴定
批准号：
3809582
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809582
关键词：
Plasmodium Plasmodium falciparum Plasmodium knowlesi Pongidae erythrocytes human tissue intracellular parasitism malaria malaria vaccines microorganism immunology protozoal antigen receptor

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中文摘要
翻译
裂殖子以受体特异性方式与红细胞相互作用 表面，是免疫可能阻止入侵的阶段。 因此，裂殖子表面组分是令人感兴趣的，因为它们在以下方面的作用： 红细胞识别和作为抗原用于诱导保护性 免疫力我们正在鉴定诺氏疟原虫、间日疟原虫和恶性疟原虫 用于附着于猴和人红细胞的受体。了解 为了研究这种变异的分子基础，我们正在研究 裂殖子表面经历抗原变异。中的部件 裂殖子与红细胞接触后的连接和信号传导 也在研究中。
英文摘要
The merozoite interacts in a receptor specific manner with the erythrocyte surface and is the stage upon which immunity may work to block invasion. Thus, merozoite surface components are of interest because of their role in erythrocyte recognition and as antigens for induction of protective immunity. We are identifying P. knowlesi, P. vivax and P. falciparum receptors for attachment to monkey and human erythrocytes. To understand the molecular basis for this variation we are studying one antigen on the merozoite surface that undergoes antigenic variation. The components in the junction and the signaling after merozoites make contact with erythrocytes is also under study.
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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
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