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EPIDERMAL TRANSGLUTAMINASES

EPIDERMAL TRANSGLUTAMINASES
表皮谷氨酰胺转胺酶
批准号：
3810939
负责人：
P STEINERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3810939
关键词：
crosslink dipeptides enzyme mechanism enzyme structure human tissue isozymes keratinization laboratory mouse lysine membrane proteins molecular cloning protein glutamine gamma glutamyltransferase protein structure function skin

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中文摘要
翻译
转谷氨酰胺酶在受体酰胺之间形成异二肽交联物 赖氨酸的谷氨基残基和供体epsilon-NH2基团。在……里面 表皮和其他层状鳞状上皮组织，这些 酶被认为参与了可能的蛋白质的交联。 以形成不溶于水的细胞膜。使用分子生物学 方法，我们发现有3种不同的转谷氨酰胺酶 正常人和小鼠表皮中的活性。这些被称为K、C 和E酶。分离克隆和鉴定克隆的工作正在进行中 对其中的每一个进行编码并确定它们的可能功能 角化正常和异常角化的表皮有不同的活性。
英文摘要
Transglutaminases form isodipeptide crosslinks between acceptor amide groups of glutaminyl residues and donor epsilon-NH2 groups of lysines. In the epidermis, and other stratified squamous epithelial tissues, these enzymes are thought to be involved in the crosslinking of putative protein components to form the insoluble cell envelope. Using molecular biology approaches, we have found that there are 3 different transglutaminase activities in normal human and mouse epidermis. These are known as the K, C and E enzymes. Work is in progress to isolate and characterize clones encoding each of these and to determine the likely functions of these different activities in normal and abnormally keratinizing epidermis.
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会议论文
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