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STUDIES ON THE IMMUNOBIOLOGY OF MALARIA

STUDIES ON THE IMMUNOBIOLOGY OF MALARIA
疟疾免疫生物学研究
批准号：
3809551
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809551
关键词：
Aotus CD4 molecule Escherichia coli Plasmodium falciparum Salmonella T lymphocyte antimicroorganism antibody erythrocytes genetic manipulation genetic recombination helper T lymphocyte host organism interaction human tissue immune response genes immunogenetics laboratory mouse malaria microorganism immunology molecular cloning protozoal antigen surface antigens

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中文摘要
翻译
某些啮齿类疟疾对无性红细胞寄生虫的免疫力 依赖于依赖于CD4+ T细胞的细胞介导机制 和脾脏，并且不依赖于抗体。 这种免疫力可以是 由沙门氏菌和疟疾抗原引起。 目前的研究是 旨在识别那些蛋白质和T细胞表位， 保护 此外，我们正在开展研究， 沙门氏菌，将导致对恶性疟原虫的保护， 澳洲猕猴
英文摘要
Immunity to asexual erythrocytic parasites in certain rodent malarias is dependent on cell mediated mechanisms that are dependent on CD4+ T cells and the spleen and are independent of antibody. Such immunity can be induced by Salmonella and malarial antigens. The present studies are designed to identify those proteins and T cell epitopes that will lead to protection. In addition, we are developing studies to test constructs in Salmonella that will lead to protection against Plasmodium falciparum in Aotus monkeys.
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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
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