Contribution of the central nervous system to peripheral neural control in obesity and diabetes.

肥胖症和糖尿病正在成为全球主要的公共卫生问题。人类肥胖型糖尿病的一个特征是肾脏和肌肉的交感神经活动显著增加。这种过度活动的原因尚不清楚，但毫无疑问涉及中枢神经系统。在大脑中有一组选定的区域能够直接影响交感神经系统的激活。我们怀疑这些区域在肥胖糖尿病患者交感神经活动过度中起着关键作用。事实上，我们相信在这些通常处于精细平衡的大脑区域中有特定的化学信使。在肥胖-糖尿病中，这种平衡被扰乱。最后，我们假设，运动，这是已知的有有益的影响，肥胖-糖尿病，恢复平衡的神经化学物质，这有助于运动的积极成果。

Obesity and diabetes are becoming major worldwide public health problems. A characteristic of human obese diabetes is a marked increase in sympathetic nerve activity to the kidneys and to the muscle. The cause of this overactivity is unknown, but undoubtedly involves the central nervous system. Within the brain are a select group of regions that are able to directly influence the activation of the sympathetic nervous system. We suspect these areas to play a critical role in the overactivity of the sympathetic nerve activity in obese diabetics. Indeed, we believe that there are specific chemical messengers in these select brain areas that are normally finely balanced. In obesity - diabetes, this balance is disturbed. Finally, we hypothesise that exercise, which is known to have beneficial effects for obesity - diabetes, restores the balance of the neurochemicals and this contributes to the positive outcomes of exercise.