Contributions of intrinsic renal cells to inflammatory renal injury

这些研究旨在提高我们对肾小球肾炎的了解，肾小球肾炎是导致肾衰竭的最常见原因。他们将研究起源于骨髓的循环白细胞(白细胞)与内在肾脏细胞在TIS疾病发展过程中的相互作用。炎症是骨髓来源的炎症细胞和血浆蛋白对各种刺激的募集的结果。随后的损伤代表了招募的细胞和靶器官内的局部细胞之间的相互作用。肾小球肾炎是一种重要的人类疾病，骨髓来源的炎症细胞和局部细胞都有可能通过产生称为细胞因子的信号分子而导致肾脏损伤。本研究将确定肾固有细胞产生的特异性细胞因子在肾小球肾炎炎性肾损伤发生发展中的作用。

These studies aim to improve our understanding of glomeruonephritis, the most common cause of kidney failure. They will study the interactions between circulating white blood cells (leukocytes) which originate from the bone marrow , and intrinsic kidney cells in the development of tis disease. Inflammation is the result of recruitment of bone marrow derived inflammatory cells and plasma proteins to a variety of stimuli. The subsequent injury represents the interaction between recruited cells and local cells within the target organ. Glomerulonephritis is an important human disease where both bone marrow derived inflammatory and local cells have the potential to contribute to kidney injury by production of signalling molecules called cytokines. This study will determine the contribution of specific cytokines produced by intrinsic renal cells towards the development of inflammatory kidney injury in GN.