PRECHRONIC TOXICITY STUDIES OF AIDS THERAPIES

本项目的目标是描述慢性前 艾滋病治疗的毒性。 NIEHS通过其致力于国家 毒理学计划，正在进行毒理学评价， 与NCI，NIAID， FDA和私人制药公司。 NIEHS计划 将为比较毒性研究提供重点， 联合治疗的研究。 在联合研究中， 重点将是获得单一药物的基线数据 在开始联合研究之前的毒性。 DDC和α的慢性前毒性研究潜力 单用干扰素、DDC联合AZT和α 干扰素与AZT组合正在研究中。 这些慢性前研究是在发育良好的啮齿动物中进行的 模型系统，强调神经行为的研究， 骨髓和生殖毒性，以及目标 器官损伤和药物分布和吸收。

The objective of this project is to characterize the prechronic toxicity of AIDS Therapies. The NIEHS, through its resource dedicated to the National Toxicology Program, is conducting toxicological evaluations of promising AIDS therapeutics in collaboration with NCI, NIAID, FDA, and private pharmaceutical firms. The NIEHS program will provide a focus for comparative toxicity studies as well as studies on combination treatments. In the combination studies, emphasis will be on obtaining baseline data on single drug toxicity before beginning combination studies. The potential for prechronic toxicity studies of DDC and alpha interferon singly, DDC in combination with AZT, and alpha interferon in combination with AZT are being investigated. These prechronic studies are done in a well developed rodent model system, emphasizing investigation of neurobehavioral, bone marrow, and reproductive toxicity, as well as of target organ damage and drug distribution and uptake.