CHRONIC TOXICITY OF METHYLPHENIDATE HYDROCHLORIDE

盐酸哌醋甲酯（CAS编号298-59-9）将在 对雄性和雌性F344/N大鼠和B6 C3 F1小鼠喂食104周， 来确定长期暴露的影响 中期试验（临床 化学和血液学、临床观察和组织病理学）将 在治疗39周和65周时进行。 临床观察，身体 早期死亡动物的体重、饲料消耗和组织病理学， 应按常规进行。 这些数据将用于确定：（1）目标 与治疗相关的器官，（2）治疗对中枢神经系统的影响 系统，骨，体重增加，肝肾功能，血清酶， 造血，（3）种属和性别之间的敏感性差异，以及 (4)致癌潜力

Methylphenidate, hydrochloride (CAS No. 298-59-9) will be administered in feed to male and female F344/N rats and B6C3F1 mice for 104 weeks, in order to determine the effects of chronic exposure. Interim tests (clinical chemistry and hematology, clinical observations, and histopathology) will be performed at 39 and 65 weeks of treatment. Clinical observations, body weights, feed consumption, and histopathology on animals dying early, will be performed routinely. This data will be used to determine: (1) target organs related to treatment, (2) effects of treatment on central nervous system, bone, weight gain, liver and kidney function, serum enzymes, hematopoiesis, (3) difference in sensitivity between species and sexes, and (4) carcinogenic potential.