BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

本计划项目资助建议书要求继续支持我们的 评估和了解磁化率效应的研究 核磁共振，并利用这些效应来检测和量化生理 功能。高磁化率对比度的动态效应 试剂是用来测量血流灌注的。内源性铁的变化 化合物是用来测量氧气消耗的。目标明确 超顺磁性氧化铁用于解剖和功能成像。 磁化率的微观变化产生了各种宏观的 后果。建议对这些影响进行协调调查，在 为了增强各种器官系统和疾病中的核磁共振成像 状态，如癌症和脑缺血。研究已经在一个 广泛的询问，包括生理、生化和生理 机械装置。 该提案分为五个相互影响的研究项目 通过使用共同的方法和人员以及 通过利用共同核心资源： 正常、缺血和肿瘤组织的核磁共振脑研究 基于顺磁性造影剂的瞬时效应和基于本征效应 组织内运动的影响； 瞬变磁共振法心肌灌注的核磁共振研究 易感性效应和使用氧化铁颗粒的脑梗塞检测 附着于抗肌球蛋白； 基于核磁共振图像的氧耗量的测量 血管内脱氧血红蛋白引起的信号变化； 微观的宏观对比后果分析 磁化率变异； 用一种新的造影剂进行核磁共振受体成像 单晶氧化铁颗粒与多种金属氧化物的结合 生物分子。 这五个项目由一个行政核心和三个核心支持 实验室：核磁共振设施核心；计算和技术核心； 和高速成像核心。

This Program Project Grant proposal requests continued support for our investigations to assess and understand magnetic susceptibility effects in NMR, and to use these effects to detect and quantify physiological function. The dynamic effects of high magnetic susceptibility contrast agents are used to measure perfusion. Alterations in endogenous iron compounds are used to measure oxygen consumption. Targeted superparamagnetic iron oxides are used for anatomic and functional imaging. Microscopic variations in susceptibility generate a variety of macroscopic consequences. A coordinated investigation of these effects is proposed, in order to enhance NMR imaging in a variety of organ systems and in disease states, such as cancer and ischemia. Research has been conducted across a wide range of inquiry, including physical, biochemical and physiological mechanisms. This proposal is divided into five research Projects which interact constructively through the use of shared methodology and personnel and through the utilization of common Core resources: NMR brain studies of normal,ischemic and neoplastic tissues based on transient effects of paramagnetic contrast agents and on intrinsic effects of motion in tissue; NMR studies of myocardial perfusion using transient magnetic susceptibility effects, and infarct detection using iron oxide particles attached to antimyosin; NMR image-based assessment of oxygen consumption by measurement of signal changes resulting from intravascular deoxyhemoglobin; Analysis of the macroscopic contrast consequences of microscopic susceptibility variation; Receptor imaging by NMR using a novel contrast agent derived from the binding of monocrystalline iron oxide particles to a variety of biomolecules. The five projects are supported by an Administrative Core and three Core laboratories: the NMR facilities Core; the Computing and Technologies Core; and the High Speed Imaging Core.