All-in-One Smart Artificial Blood Vessels

心血管疾病（cvd）是全世界致残和死亡的主要原因。据世界心脏联合会统计，全球每年有1730多万人死于心血管疾病，占全球疾病死亡总数的31%。血管重构对心血管疾病的治疗具有重要意义，但适合自体移植的患者不到30%，因此人工血管成为不可缺少的替代方案。虽然结构可编程纺织人工血管已被证明具有临床应用的资格，但由于无法监测血管状况，人工血管的炎症、血栓或堵塞等问题仍然威胁着人类的生命。因此，该项目的目标是开发能够实时检测血管状况的一体化智能人工血管（smartvessel）。智能船舶的设计将结合电子纺织结构设计和生物工程技术，以实现良好的合规性、生物相容性、可持续性和功能性。我们将制造生物相容性导电纤维，并将其加工成单电极摩擦电纱线，并利用编织技术制造空心结构的smartvessel。织物结构中的导电纤维和摩擦电纱线将实现无线信号的采集和传输。当血液通过通道时，根据电双层理论会产生电信号，从而可以评估和诊断反映血管状况的血流速度。我们设想未来，我们将能够在早期阶段使用纺织人造血管检测和监测心血管疾病。

Cardiovascular disease (CVDs) are the leading causes of disability and death worldwide. According to statistics from the World Heart Federation, more than 17.3 million people died from CVDs worldwide per year, accounting for 31% of the total global disease deaths. Vascular remodeling has great significance for the treatment of CVDs, but less than 30% of patients are eligible for autologous transplants, so artificial blood vessels become an indispensable alternative. Although structure-programmable textile artificial blood vessels are proved to qualify for clinical usage, problems such as inflammation, thrombus or blockage of artificial blood vessels are still threatening human life due to the inability to monitor blood vessel conditions. Therefore, the aim of this project is to develop all-in-one smart artificial blood vessel (SmartVessels) that can detect vessel conditions in real-time. The SmartVessels will be designed by combining electronic textile architecture design and bioengineering technology to achieve good compliance, biocompatibility, sustainability, and functionality. We will fabricate biocompatible conductive fibers, and process them into single-electrode triboelectric yarns, and use weaving technologies to fabricate hollow structured SmartVessels. The conductive fibers and triboelectric yarns in the fabric structure will enable wireless signal acquisition and transmission. When blood passes through the channel, electrical signals will be generated according to the electric double layer theory, thereby the blood flow velocity that reflect the vessels conditions can be evaluated and diagnosed. We envision a future where we will be able to detect and monitor CVDs in an early stage using textile artificial blood vessels.