RECEPTORS FOR INVASION OF HOST CELLS AND ADHESION TO ENDOTHELIUM

裂殖子和受感染的红细胞在受体中相互作用- 分别以红细胞和内皮细胞的特异性方式作用于 促进红细胞的侵袭和细胞对内皮的黏附。这些 步骤在疟疾的发病机制中是关键的，也是 用于阻止入侵和细胞黏附的疫苗和药物。我们是 诺氏疟原虫、间日疟原虫和恶性疟原虫三种寄生虫配体的鉴定 以及侵袭宿主受体和抗原性的分子基础 变种。红细胞表面的一种与抗原性有关的抗原 变异和细胞黏附一直是研究的焦点，因为它 对发病机制的重要性，包括其具有与 参与红细胞入侵的寄生虫分子。中的组件 疟疾裂殖子与弓形虫的连接及其信号转导 弓形虫与宿主细胞的接触也在研究中。

The merozoite and the infected erythrocyte interact in a receptor- specific manner with erythrocyte and endothelium, respectively, to promote invasion of erythrocytes and cytoadherence to endothelium. These steps are critical in the pathogenesis of malaria and are targets for vaccines and drugs to block invasion and cytoadherence. We are identifying the P. knowlesi, P. vivax and P. falciparum parasite ligands and the host receptors for invasion and the molecular basis of antigenic variation. An antigen on the erythrocyte surface involved in antigenic variation and cytoadherence has been the focus of study because of its importance to pathogenesis, including its having the same motif as the parasite molecule involved in erythrocyte invasion. The components in the junction and the signaling after malaria merozoites and Toxoplasma gondii make contact with their host cells is also under study.