SEARCH FOR NEW HEPATITIS AGENTS

1989年，巨细胞性肝炎的一种可能的副粘病毒病原学是 建议，基于在肝脏中看到的电子显微变化 患有这种疾病的病人。试图将疾病传播给灵长类动物 已经启动了。 意大利撒丁岛的地中海贫血患者每月接受血液治疗 输血作为治疗手段。这些患者中的许多人已经发展成慢性 原因不明的肝炎。这些病人正在接受研究 以前未被识别的肝炎病毒的证据。同样， 急、慢性非甲、乙、丙、丁、戊型肺炎患者的临床样本 美国的肝炎正在进行生物学研究， 传播剂的血清学或分子证据。 暴发型非甲、非乙型肝炎患者仍是诊断之谜 并且可能感染了一种或多种以前未识别的病毒。 我们正试图将这种疾病传播给灵长类动物。 另一种水媒肝炎病毒存在的证据 来自印度和沙特阿拉伯的血清流行病学研究。从… 16起水源性肝炎疫情中肝炎病例的50%~100% 都是由HEV引起的，但1起水媒疫情是由这两种甲型肝炎病毒引起的 也不是混合动力车。同样，在沙特阿拉伯，13.4%的成人急性肝炎 不能被诊断为甲型至戊型肝炎，似乎是通过传播的 通过非肠外途径。 几年前，据报道，一种肝炎病毒可以从 非甲非乙型肝炎患者给猴猴。这名特工被称为 GB制剂可以在绒猴中连续传播，并被 有部分特征的。最近，GB试剂被克隆和测序 并被证明与之前未被识别的人类有远亲关系 病毒。其他人则独立发现了另一种人类病毒。 GB试剂和新发现的人类病毒正在进行研究 灵长类动物和体外培养。 该项目的目标是确定和描述新的 肝炎的病原体和开发有用的诊断方法 感染和血清流行病学研究。一个长期目标是 这些人的被动和主动免疫预防的研究进展 病原体。

In 1989 a possible paramyxovirus etiology for giant cell hepatitis was proposed, based on electron micrographic changes seen in the livers of patients with this disease. Attempts to transmit the disease to primates have been initiated. Patients with thalassemia in Sardinia, Italy, receive monthly blood transfusions as therapy. Many of these patients have developed chronic hepatitis of unknown etiology. These patients are being studied for evidence of previously unrecognized hepatitis viruses. Similarly, clinical samples from patients with acute or chronic non-A, B, C, D, E hepatitis in the United States are being studied for biological, serological or molecular evidence of transmissible agents. Patients with fulminant non-A, non-B hepatitis remain a diagnostic enigma and may be infected with one or more previously unrecognized viruses. We are attempting to transmit the disease to primates. Evidence for the existence of an additional water-borne hepatitis virus has come from sero-epidemiologic studies in India and Saudi Arabia. From 50-100% of hepatitis cases in sixteen epidemics of water-borne hepatitis were caused by HEV but 1 water-borne epidemic was caused by neither HAV nor HEV. Similarly, in Saudi Arabia, 13.4% of acute hepatitis in adults could not be diagnosed as hepatitis A-E and appeared to be transmitted by nonparenteral means. Some years ago, a hepatitis virus was reported to be transmissible from a non-A, non-B hepatitis patient to marmoset monkeys. The agent, called the GB agent, could be serially transmitted in marmosets and was partially characterized. Recently the GB agent was cloned and sequenced and shown to be distantly related to a previously unrecognized human virus. Others have independently discovered an additional human virus. The GB agent and the newly discovered human viruses are being studied in primates and in vitro. The objectives of this project are to identify and characterize new etiologic agents of hepatitis and to develop useful assays for diagnosis of infection and seroepidemiologic studies. A long-term objective is the development of passive and active immunoprophylaxis for these human pathogens.