SUPer-REsolution non-invasive Muscle measurements with miniaturised magnetIc SEnsors (SUPREMISE)

肌肉活动的评估已经成为医学诊断、运动康复、健康监测和神经假体/机器人控制的重要指标。最近的技术进步使影响肌肉和周围神经的疾病能够被远程和连续地记录和诊断。为了探索分娩前子宫的电生理行为，磁肌图(MMG)被用于孕期健康监测。此外，MMG还可用于康复，例如创伤性神经损伤、脊髓损伤和卡压综合征。SUPREMISE是一项雄心勃勃、推测性、跨学科和创造性的研究联谊会计划，有可能解决未满足的临床问题，导致肌肉运动记录的全新技术，在神经肌肉患者和其他领域创造范式转变，例如用于扩展现实、游戏和消费电子产品的人机界面。在这项研究中创造的发现、研究和新知识将导致一个世界领先的研究小组，使英国处于这一新兴领域的前沿。SuPREMISE将创造第一个可穿戴的自旋电子传感器，用于在临床环境中测量MMG信号。SUPREMISE将涉及磁性传感器、微电子学、可穿戴设备、肌肉神经科学和信号处理方面的根本性创新。一个主要目标是通过开发基于自旋电子学的新型传感诊断可穿戴设备来记录和测量肌肉活动，从而对受神经肌肉疾病影响的患者的生活产生革命性影响。通过将尖端的理论、计算和实验物理与先进的生物医学建模和测试相结合，将提出一种范式转换的工程技术。虽然与神经肌肉疾病有关的肌肉活动引起了医疗保健界的注意，但磁记录诊断方法尚未通过一个强大和可靠的工具得到系统应用。SUPREMISE将使MMG传感器的有效使用标准化，以检测此类肌肉活动，以便临床部署。小型化的磁传感系统提供了用易于使用的可穿戴临床平台取代笨重的实验室仪器的前景。它将使成本(&lt；GB 5)、尺寸和噪音底限降低几个数量级。在这里，我们提出了一种新的解决方案，使用集成了ASIC读出接口的纳米级自旋电子TMR传感器。这种新的可穿戴系统占地面积小，具有出色的灵敏度、超低噪声和卓越的空间分辨率，可以检测肌肉产生的低皮特斯拉(PT)磁场。鉴于我发表的和同行评议的试点研究，我相信我们正处于建模和实验工作相结合将加快进展的阶段。该项目的成果将致力于开发一种新的微型肌肉分析平台，改进MMG信号的测量并简化供临床医生使用的技术。

The assessment of muscle activity has become an essential indicator in medical diagnosis, motor rehabilitation, health monitoring, and neuroprosthetic/robotic control. Recent technological advances allow diseases that affect muscles and peripheral nerves to be recorded and diagnosed remotely and continuously. Motivated by exploring the electrophysiological behaviour of the uterus before childbirth, magnetomyography (MMG) was used for health monitoring during pregnancy. In addition, MMG can be used to rehabilitate, for example, traumatic nerve injuries, spinal cord lesions, and entrapment syndrome.SUPREMISE is an ambitious, speculative, interdisciplinary, and creative fellowship programme of research that has the potential to address unmet clinical, leading to radically new technologies for muscle movement recording, creating a paradigm shift in neuromuscular patients and beyond e.g. human-machine interfacing for extended reality, gaming, and consumer electronics. The discoveries, research and new knowledge created within this fellowship will lead to a world-leading research group that will position the UK at the forefront of this emergent field. SUPREMISE will create the first wearable spintronic sensor for measuring MMG signals in the clinical setting. SUPREMISE will involve radical innovations in magnetic sensors, microelectronics, wearable devices, muscle neuroscience, and signal processing. A principal aim is to make a transformative impact on the lives of patients affected by neuromuscular diseases by developing novel sensing diagnosis wearables based on spintronics that record and measure muscle activity. A paradigm-shifting engineering technology will be proposed by interfacing cutting-edge theoretical, computational, and experimental physics with advanced biomedical modelling and testing. While muscle activity which is linked to neuromuscular diseases, has captured the attention of the healthcare community, the magnetic recording approach to diagnosis has not been systematically applied through a robust and reliable tool. SUPREMISE will standardize the efficient utilization of the MMG sensor to detect such muscle activity for clinical deployment. Miniaturizing magnetic sensing systems offer the prospect of replacing bulky laboratory instruments with easy-to-use wearable clinical platforms. It would decrease the cost (< £5), size, and noise floor by several orders of magnitude. Here, we propose a novel solution using nanofabricated spintronic TMR-based sensors integrated with the ASIC readout interface. This new wearable system with a small footprint, excellent sensitivity, ultralow noise, and excellent spatial resolution can detect low pico-Tesla (pT) magnetic fields generated by the muscle. Given my published and peer-reviewed pilot research, I believe that we are at the stage where a combination of modelling and experimental work will accelerate progress. The project's results will target the development of a new miniaturized platform for muscle assays that refines the measurement of the MMG signals and streamlines techniques for use by clinicians.