Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy

CardioSCOPE提案旨在汇集来自欧洲各地公司和学术界的专家，交流和扩大他们在跨学科方法方面的专业知识，以增强欧洲在心血管疾病领域的研究和创新能力。CardioSCOPE通过全面的多组学方法连接和扩展欧洲范围内的生物库和专业知识，发现新的病理参与者，将更深入地了解急性冠脉综合征（ACS）的发展和主要不良心血管事件（MACE）的进展。我们将使用明确的前瞻性队列来发现和验证ACS和MACE特异性的新的基因组、转录组、蛋白质组和代谢组特征，并通过机器学习/人工智能算法将其结合到多标记模型中，从而实现更准确的ACS诊断和MACE预测。这个优秀的研究网络旨在通过培训和知识转移培养能够胜任即将到来的“组学时代”的科学家。在国内机构无法获得的特定研究技能将通过个人设计的借调计划、培训学校、网络研讨会和短期课程获得。部门间活动将提高财团工作人员的企业技能，并促进将科学突破转化为商业上可获得的产品/服务。CardioSCOPE包括具有广泛临床和研究经验的专家，能够接触到ACS患者和实现既定目标所需的专业知识。在该联盟中聚集的世界一流机构（来自6个国家- 7个学术机构，4家公司，1家医院）提供专门知识，最先进的设备和充足的人力资源来应对这些挑战。总之，该项目的结果将超越我们自己的科学兴趣，使知识转移到多学科环境中，并对欧洲的ACS管理和政策产生重大影响。

The CardioSCOPE proposal aims to bring together experts from companies and academia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming 'omics era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designedsecondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries - 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.