BASIC MECHANISMS OF AGING AND AGE-RELATED DISEASES

我们的最终目标是试图解开多方面的进程， 老化并将其减少到有限数量的明确分子 可能与环境因素相互作用的过程。 这应该 让我们深入了解衰老的基本机制， 早期诊断和医疗干预的可能性。 我们计划 将衰老的基础分子研究与生理学研究紧密结合起来， 端点。 事实上，为了最佳地利用最近新的意外之财， 先进的分子生物学技术对老年医学的好处， 最重要的是把基础研究和 函数相关性 作为这方面的一个模式，我们采用了 假设DNA损伤、突变和功能障碍有助于 衰老过程中的生理衰退和疾病。 使用最新的 技术，我们将研究（1）体细胞突变频率，（2）相对 DNA修复能力，（3）基因表达调控，和（4） 线粒体能量学 这将允许我们定义一个角色，如果有的话， DNA的变化在特定的衰老问题。 增加值 我们将能够将不同的数据集与一个 另 最后，该项目可以作为未来的模式 分子参数与功能结局的研究。

Our ultimate goal is to attempt to unravel the multifaceted process of aging and reduce it to a finite number of well-defined molecular processes that likely interact with environmental factors. This should give us insight into the basic mechanisms of aging and provide new possibilities for early diagnosis and medical intervention. We plan to closely couple basic molecular studies on aging to physiological endpoints. Indeed, to optimally apply the recent windfall of new advanced techniques in molecular biology to the benefit of gerontology, it is of the utmost importance to bring together basic research and functional correlations. As a model for this we have adopted the hypothesis that DNA damage, mutation and dysfunction contribute to physiological decline and disease during aging. Using the latest technology, we will study (1) somatic mutation frequency, (2) relative DNA repair proficiency, (3) gene expression regulation, and (4) mitochondrial energetics. This will allow us to define a role, if any, of DNA changes in specific aging problems. The added value of the program is that we will be able to relate the different data sets to one another. Finally, the program project could serve as a model for future studies on molecular parameters in conjunction with functional outcomes.