ESTABLISHMENT OF HCV CONTAINING CELL CULTURE

丙型肝炎病毒(HCV)的基因组是大多数后遗症的病原体。 输血非甲型、非乙型病例，是一种阳性的链状RNA病毒。这个 黑猩猩的易感性使得连续采集血液和 所有感染阶段的肝脏活检，但没有完整的病毒粒子 令人信服地被孤立了。这可能是失败的一个原因 说明这些试剂(S)对检测病毒样抗原是非常有效的 病毒在受感染主机中的复制程度有限，如建议的那样 大多数血浆的感染性滴度较低。我们预计， 肝细胞原代培养的发展可能被证明是敏感的。

The genome of hepatitis C virus (HCV), the etiologic agent of most post- transfusion non-A, non-B cases, is a positive stranded RNA virus. The susceptibility of chimpanzees has allowed collection of serial blood and liver biopsies from all stages of infection, yet no complete virions have been convincingly isolated. A likely reason for the failure to demonstrate these agent(s) or to detect virus-like antigens is the very limited degree of viral replication in the infected host, as suggested by low infectivity titer of most plasma. We anticipate that the development of a primary culture of liver cells might prove susceptible.