Correlation of methylation profiles with cancer testis antigen expression and response to chemotherapy in non small cell lung cancer

免疫疗法是治疗肺癌的一种新概念。睾丸癌抗原（CTA，如NY-ESO-1）是一种与预后不良相关的免疫原性分子，但我们最近的研究发现，表达NY-ESO-1的肿瘤对化疗的反应更强。我们还能够使用去甲基化剂在通常不表达NY-ESO-1的细胞中诱导其表达。我们的目标是确定我们是否可以通过联合使用这些药物来增加对化疗的反应。

Immunotherapy is a new concept treatment for lung cancer. Cancer testis antigen (CTA, eg NY-ESO-1) is an immunogenic molecule that was related with poor outcomes, but our recent studies have found that tumours that express NY-ESO-1 are more responsive to chemotherapy. We are also able to induce expression of NY-ESO-1 in cells that do not normally express it using demethylating agents. We aim to determine if we can increase the response to chemotherapy by using these drugs in combination.