PHYSICS OF IONIC CHANNELS AND OTHER PROTEINS WITH AQUEOUS CAVITIES

已经观察到由多肽阿米西林制成的通道，而 受到不同大小的中性聚合物的渗透作用。 不仅可以看到聚合物的渗透程度 从它们的渗透作用进入经络，也要遵循 小分子聚合物在离子通道中的运动动力学。 这些通道对磷脂敏感的双层进入 它们被合并在一起，特别是有很强的相关性 在高电导态的概率和电子的趋势之间 磷脂形成非片层结构。 霍夫迈斯特效应适用于离子的输运性质 频道。热致阴离子与罗法拉米币通道结合的时间更长 倍数，增加其电导并诱导阳离子选择性 根据他们在霍夫迈斯特系列中的位置。 在关于血红蛋白氧合的实验中，证明了对于 弱结合反应渗透压对结合的贡献可以是 与溶质结合的直接贡献一样显著。

Channels made from the peptide alamethicin have been observed while subjected to the osmotic action of differently sized neutral polymers. It is possible not only to see the degree of penetration of the polymers into the channel from their osmotic action but also to follow the kinetics of motion of small polymers through the ionic channel. These channels are sensitive to the phospholipid of the bilayer into which they are incorporated, in particular there is a strong correlation between the probability of high-conductance states and the tendency of the phospholipid to form non-lamellar structures. Hofmeister effect is shown to apply to transport properties of ionic channels. Chaotropic anions bind to roflamycoin channels for longer times, increase their conductance and induce cationic selectivity according to their position in Hofmeister series. In experiments on hemoglobin oxygenation, it is demonstrated that for weak binding reactions the osmotic contributions to binding can be as significant as the direct contribution from solute binding.