MOLECULAR FORCES IN CELLUALR ORGANIZATION AND FUNCTION

细胞组织和功能中的分子力

• 批准号: 3853607
• 负责人: V A PARSEGIAN
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853607
• 关键词: cell biology; cell membrane; cell osmotic pressure; macromolecule

The theme of our work has been to measure, to identify, and to formulate the forces that are important to the organization of macromolecules and membranes. Specifically, using the osmotic stress technique we have measured force vs. distance between membranes or between macromolecules in ordered arrays. We have found that the nature of the forces previously and still commonly assumed in order to explain molecular organization and subcellular assembly are not accurate. Happily, though, the fairly extensive catalog of information that we are acquiring is allowing us to open new ways to think about the molecular basis of cellular function.

我们工作的主题一直是衡量、识别和制定 对大分子的组织和结构至关重要的力 膜。 具体地说，使用渗透应激技术，我们测量了力与 有序排列的膜之间或大分子之间的距离。我们 已经发现以前和现在普遍存在的部队性质 假设是为了解释分子组织和亚细胞组装 是不准确的。不过，令人高兴的是，相当广泛的 我们正在获取的信息使我们打开了新的思考方式 关于细胞功能的分子基础。