ASSESSMENT OF ALCOHOL CONSUMPTION BY TRANSDERMAL ETHANOL

长期饮酒的可靠衡量标准是 对研究应用、监测治疗结果和 法医应用。已经开发了各种方法来 评估酒精消费，包括口头报告，生化标记物， 以及直接测量血液、尿液和其他体液，如 汗流浃背。然而，没有一种单一的方法可以轻松可靠地 确定长期饮酒的数量和模式。 一个原型装置，经皮酒精传感器(TAS)已经被 开发了一种使用电化学检测透皮乙醇的方法， 以短时间间隔重复采样乙醇浓度，以及固体- 将数据存储在状态数天至数周的时间段以监控乙醇 消费。受控人群饮酒情况的初步研究 设置表明TAS能够确定图案和 以半定量的方式表示酒精消耗量的相对量。这个 TAS器件表现出良好的灵敏度，检测阈值低至10 20 mg/dl。 这项建议包括三项研究，这些研究将评估 助教作为研究工具，更好地理解酒精的各个方面 在人类中的消耗。我们将使用TAS：(L)来更好地理解 乙醇经皮吸收在多种人体的药代动力学 种族、性别和皮肤状况的不同，并对该设备进行试点测试 对于非酒精饮酒者，在已知酒精消费的情况下 在家庭环境中；(2)在以下情况下对不含酒精的饮酒者进行现场试验 自然饮酒条件；3)门诊有酗酒者 治疗。我们将评估TAS设备的实用性和接受度，并 将其评估酒精消费的能力与传统的 评估措施，如自我报告、抵押品报告和 临床医生评估。

The reliable measurement of alcohol consumption over long time periods is important for research applications, monitoring treatment outcome and for forensic applications. A variety of methodologies have been developed to assess alcohol consumption, including verbal report, biochemical markers, and direct measurement of blood, urine and other body fluids such as sweat. Yet, no single method exists which can easily and reliably determine the amount and pattern of alcohol consumption over long periods. A prototype device, the Transdermal Alcohol Sensor (TAS) has been developed which uses electrochemical detection of transdermal ethanol, repeated sampling of ethanol concentration at short intervals, and solid- state storage of the data for periods of days to weeks to monitor ethanol consumption. Preliminary studies on alcohol consumption in controlled settings indicate that the TAS is capable of determining the pattern and relative amount of alcohol consumption in a semi-quantitative fashion. The TAS device shows good sensitivity with-threshold detection as low as 10 - 20 mg/dl. This proposal consists of three studies which will evaluate the use of the TAS as a research tool to better understand various aspects of alcohol consumption in humans. We will use the TAS: (l) to better understand the pharmacokinetics of transcutaneous ethanol across a range of individuals differing in race, gender and skin conditions and to pilot test the device in non-alcoholic drinkers, under conditions of known alcohol consumption in a home setting; (2) in field-trials with non-alcoholic drinkers under naturalistic drinking conditions; and 3) with alcoholics in outpatient treatment. We will evaluate utility and acceptance of the TAS device and compare its ability to assess alcohol consumption with traditional measures of assessment, such as self-report, collateral report and clinician assessment.