Yeast-based solutions for sustainable Aviation Fuels (YAF)

可持续航空燃料（SAF）是航空业中化石燃料的唯一短期替代品。考虑到在不久的将来预计乘客人数会增加，预计未来几年SAF的产量将大幅增加。为了满足这一需求的增长，需要将现有的和新的可再生能源生产链结合起来。目前的SAF生产途径处于不同的成熟、实施甚至商业化水平。然而，降低成本和供应链发展是商业规模SAF部署的关键挑战。使用生物废物作为SAF的原料具有挑战性，但必须使SAF与化石燃料竞争。在这种情况下，酵母可能是以环境友好的方式从生物废物中产生经济上可行的SAF中间体（萜烯或脂肪酸（FA））的关键参与者。这种通过生物手段生产SAF的做法是非常新的，并提出了许多必须解决的剩余挑战和培训差距。YAF研究计划旨在：i）从生物废弃物中生产碳源，ii）开发新的酵母细胞工厂以生产SAF，iii）设计新的双功能催化剂，iv）实现FA/萜烯提取的有效策略，以及v）创建针对不同SAF生产路线的放大方法和生命周期可持续性评估的强大框架，这将支持决策。为了实现这一目标，将需要生物学、生物技术、化学工程和环境科学的正确整合。因此，YAF的主要培训/网络目标是在高度跨学科和跨部门的研究环境中培训下一代研究人员，以便他们能够妥善应对即将到来的基于SAF的生产酵母的挑战。YAF旨在加强欧洲的研究和创新，提高研究的知名度，并产生临界质量，以应对欧洲（和全球）的挑战

Sustainable aviation fuels (SAF) are the only short-term alternative to fossil fuels in aviation. Considering the increased number of passengers forecasted in the near future, a massive increased in SAF production has been estimated in the years to come. To fulfill this increase in demand, the combination of existing and new renewable production chains is needed. Current SAF-producing pathways are at different levels of maturity, implementation or even commercialization. However, lowering the cost and supply chain development are key challenges for commercial-scale SAF deployment. Using biowastes as feedstock for SAF is challenging but necessary to make SAF competitive with fossil fuels. In this context, yeasts may be key players to generate economically-viable SAF intermediates (terpenes or fatty acids (FA)) in an environmentally-friendly way from biowaste. This SAF production by biological means is very new and presents a lot of remaining challenges and training gaps that have to be addressed. YAF research programme aims at; i) producing carbon sources from biowastes, ii) developing new yeast cell factories to produce SAF, iii) designing new bifunctional catalysts, iv) achieving efficient strategies for FA/terpenes extraction, and v) creating robust framework tailored to the scaling-up methodologies and life-cycle sustainability assessment of different SAF producing routes, which will support decisionmaking. To achieve this, the right integration of biology, biotechnology, chemical engineering and environmental sciences will be required. Thus, the prime training/networking aim of YAF is to train the next generation of researchers in a highly interdisciplinary and intersectorial research environment such that they can soundly address upcoming challenges concerning production yeast based SAF. YAF has been designed to strengthen European research and innovation, enhancing research visibility and generating a critical mass to address European (and global) challenges